DIRAS2 is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders
Identifieur interne : 000920 ( Main/Exploration ); précédent : 000919; suivant : 000921DIRAS2 is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders
Auteurs : Andreas Reif [Allemagne] ; T Trang Nguyen [Allemagne] ; Lena Wei Flog [Allemagne] ; Christian P. Jacob [Allemagne] ; Marcel Romanos [Allemagne] ; Tobias J. Renner [Allemagne] ; Henriette N. Buttenschon [Danemark] ; Sarah Kittel-Schneider [Allemagne] ; Alexandra Gessner [Allemagne] ; Heike Weber [Allemagne] ; Maria Neuner [Allemagne] ; Silke Gross-Lesch [Allemagne] ; Karin Zamzow [Allemagne] ; Susanne Kreiker [Allemagne] ; Susanne Walitza [Suisse] ; Jobst Meyer [Allemagne] ; Christine M. Freitag [Allemagne] ; Rosa Bosch [Espagne] ; Miquel Casas [Espagne] ; Nuria G Mez [Espagne] ; Marta Ribasès [Espagne] ; M Nica Bayès [Espagne] ; Jan K. Buitelaar [Pays-Bas] ; Lambertus A L M. Kiemeney [Pays-Bas] ; J J Sandra Kooij [Pays-Bas] ; Cees C. Kan [Pays-Bas] ; Martine Hoogman [Pays-Bas] ; Stefan Johansson [Norvège] ; Kaya K. Jacobsen [Norvège] ; Per M. Knappskog [Norvège] ; Ole B. Fasmer [Norvège] ; Phil Asherson [Royaume-Uni] ; Andreas Warnke [Allemagne] ; Hans-Jörgen Grabe [Allemagne] ; Jessie Mahler [Allemagne] ; Alexander Teumer [Allemagne] ; Henry Völzke [Allemagne] ; Ole N. Mors [Danemark] ; Helmut Sch Fer [Allemagne] ; Josep Antoni Ramos-Quiroga [Espagne] ; Bru Cormand [Espagne] ; Jan Haavik [Norvège] ; Barbara Franke [Pays-Bas] ; Klaus-Peter Lesch [Allemagne]Source :
- Neuropsychopharmacology [ 0893-133X ] ; 2011.
Abstract
Several linkage analyses implicated the chromosome 9q22 region in attention deficit/hyperactivity disorder (ADHD), a neurodevelopmental disease with remarkable persistence into adulthood. This locus contains the brain-expressed GTP-binding RAS-like 2 gene (
Url:
DOI: 10.1038/npp.2011.120
PubMed: 21750579
PubMed Central: 3176568
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000003
- to stream Pmc, to step Curation: 000003
- to stream Pmc, to step Checkpoint: 000137
- to stream Ncbi, to step Merge: 000473
- to stream Ncbi, to step Curation: 000473
- to stream Ncbi, to step Checkpoint: 000473
- to stream Main, to step Merge: 000951
- to stream Main, to step Curation: 000920
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>DIRAS2</italic> is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders</title><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nguyen, T Trang" sort="Nguyen, T Trang" uniqKey="Nguyen T" first="T Trang" last="Nguyen">T Trang Nguyen</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Medical Biometry and Epidemiology, University of Marburg</institution>, Marburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wei Flog, Lena" sort="Wei Flog, Lena" uniqKey="Wei Flog L" first="Lena" last="Wei Flog">Lena Wei Flog</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</institution>, Wuerzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jacob, Christian P" sort="Jacob, Christian P" uniqKey="Jacob C" first="Christian P" last="Jacob">Christian P. Jacob</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</institution>, Wuerzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J" last="Renner">Tobias J. Renner</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buttenschon, Henriette N" sort="Buttenschon, Henriette N" uniqKey="Buttenschon H" first="Henriette N" last="Buttenschon">Henriette N. Buttenschon</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Centre for Psychiatric Research, Aarhus University Hospital</institution>, Risskov,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kittel Schneider, Sarah" sort="Kittel Schneider, Sarah" uniqKey="Kittel Schneider S" first="Sarah" last="Kittel-Schneider">Sarah Kittel-Schneider</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gessner, Alexandra" sort="Gessner, Alexandra" uniqKey="Gessner A" first="Alexandra" last="Gessner">Alexandra Gessner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weber, Heike" sort="Weber, Heike" uniqKey="Weber H" first="Heike" last="Weber">Heike Weber</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neuner, Maria" sort="Neuner, Maria" uniqKey="Neuner M" first="Maria" last="Neuner">Maria Neuner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gross Lesch, Silke" sort="Gross Lesch, Silke" uniqKey="Gross Lesch S" first="Silke" last="Gross-Lesch">Silke Gross-Lesch</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</institution>, Wuerzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zamzow, Karin" sort="Zamzow, Karin" uniqKey="Zamzow K" first="Karin" last="Zamzow">Karin Zamzow</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Medical Biometry and Epidemiology, University of Marburg</institution>, Marburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kreiker, Susanne" sort="Kreiker, Susanne" uniqKey="Kreiker S" first="Susanne" last="Kreiker">Susanne Kreiker</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</institution>, Wuerzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Walitza, Susanne" sort="Walitza, Susanne" uniqKey="Walitza S" first="Susanne" last="Walitza">Susanne Walitza</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Child and Adolescent Psychiatry, University of Zuerich</institution>, Zuerich,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Neurobehavioral Genetics, University of Trier, Institute of Psychobiology</institution>, Trier,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Freitag, Christine M" sort="Freitag, Christine M" uniqKey="Freitag C" first="Christine M" last="Freitag">Christine M. Freitag</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Child and Adolescent Psychiatry, Goethe University Frankfurt am Main</institution>, Frankfurt,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bosch, Rosa" sort="Bosch, Rosa" uniqKey="Bosch R" first="Rosa" last="Bosch">Rosa Bosch</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Psychiatry, Hospital Universitari Vall d'Hebron</institution>, Barcelona, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Casas, Miquel" sort="Casas, Miquel" uniqKey="Casas M" first="Miquel" last="Casas">Miquel Casas</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Psychiatry, Hospital Universitari Vall d'Hebron</institution>, Barcelona, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="G Mez, Nuria" sort="G Mez, Nuria" uniqKey="G Mez N" first="Nuria" last="G Mez">Nuria G Mez</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Psychiatry, Hospital Universitari Vall d'Hebron</institution>, Barcelona, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ribases, Marta" sort="Ribases, Marta" uniqKey="Ribases M" first="Marta" last="Ribasès">Marta Ribasès</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Psychiatry, Hospital Universitari Vall d'Hebron</institution>, Barcelona, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bayes, M Nica" sort="Bayes, M Nica" uniqKey="Bayes M" first="M Nica" last="Bayès">M Nica Bayès</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Centro Nacional de Análisis Genómico (CNAG)</institution>, Barcelona, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buitelaar, Jan K" sort="Buitelaar, Jan K" uniqKey="Buitelaar J" first="Jan K" last="Buitelaar">Jan K. Buitelaar</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</institution>, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kiemeney, Lambertus A L M" sort="Kiemeney, Lambertus A L M" uniqKey="Kiemeney L" first="Lambertus A L M" last="Kiemeney">Lambertus A L M. Kiemeney</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre</institution>, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kooij, J J Sandra" sort="Kooij, J J Sandra" uniqKey="Kooij J" first="J J Sandra" last="Kooij">J J Sandra Kooij</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>PsyQ, Psycho-Medical Programs, Program Adult ADHD</institution>, The Hague,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kan, Cees C" sort="Kan, Cees C" uniqKey="Kan C" first="Cees C" last="Kan">Cees C. Kan</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</institution>, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hoogman, Martine" sort="Hoogman, Martine" uniqKey="Hoogman M" first="Martine" last="Hoogman">Martine Hoogman</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</institution>, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Stefan" sort="Johansson, Stefan" uniqKey="Johansson S" first="Stefan" last="Johansson">Stefan Johansson</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Biomedicine, University of Bergen</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jacobsen, Kaya K" sort="Jacobsen, Kaya K" uniqKey="Jacobsen K" first="Kaya K" last="Jacobsen">Kaya K. Jacobsen</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Biomedicine, University of Bergen</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Knappskog, Per M" sort="Knappskog, Per M" uniqKey="Knappskog P" first="Per M" last="Knappskog">Per M. Knappskog</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fasmer, Ole B" sort="Fasmer, Ole B" uniqKey="Fasmer O" first="Ole B" last="Fasmer">Ole B. Fasmer</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Division of Psychiatry, Haukeland University Hospital</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Asherson, Phil" sort="Asherson, Phil" uniqKey="Asherson P" first="Phil" last="Asherson">Phil Asherson</name><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grabe, Hans Jorgen" sort="Grabe, Hans Jorgen" uniqKey="Grabe H" first="Hans-Jörgen" last="Grabe">Hans-Jörgen Grabe</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Psychiatry and Psychotherapy, University of Greifswald</institution>, Greifswald,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mahler, Jessie" sort="Mahler, Jessie" uniqKey="Mahler J" first="Jessie" last="Mahler">Jessie Mahler</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Psychiatry and Psychotherapy, University of Greifswald</institution>, Greifswald,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>, Greifswald,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Institute for Community Medicine, University of Greifswald</institution>, Greifswald,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mors, Ole N" sort="Mors, Ole N" uniqKey="Mors O" first="Ole N" last="Mors">Ole N. Mors</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Centre for Psychiatric Research, Aarhus University Hospital</institution>, Risskov,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sch Fer, Helmut" sort="Sch Fer, Helmut" uniqKey="Sch Fer H" first="Helmut" last="Sch Fer">Helmut Sch Fer</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Medical Biometry and Epidemiology, University of Marburg</institution>, Marburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ramos Quiroga, Josep Antoni" sort="Ramos Quiroga, Josep Antoni" uniqKey="Ramos Quiroga J" first="Josep Antoni" last="Ramos-Quiroga">Josep Antoni Ramos-Quiroga</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Psychiatry, Hospital Universitari Vall d'Hebron</institution>, Barcelona, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cormand, Bru" sort="Cormand, Bru" uniqKey="Cormand B" first="Bru" last="Cormand">Bru Cormand</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, and CIBER Enfermedades Raras, and Institut de Biomedicina de la Universitat de Barcelona (IBUB)</institution>, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haavik, Jan" sort="Haavik, Jan" uniqKey="Haavik J" first="Jan" last="Haavik">Jan Haavik</name><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Biomedicine, University of Bergen</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Division of Psychiatry, Haukeland University Hospital</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</institution>, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Human Genetics, Radboud University Nijmegen Medical Center</institution>, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lesch, Klaus Peter" sort="Lesch, Klaus Peter" uniqKey="Lesch K" first="Klaus-Peter" last="Lesch">Klaus-Peter Lesch</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</institution>, Wuerzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21750579</idno><idno type="pmc">3176568</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176568</idno><idno type="RBID">PMC:3176568</idno><idno type="doi">10.1038/npp.2011.120</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000003</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000003</idno><idno type="wicri:Area/Pmc/Curation">000003</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000003</idno><idno type="wicri:Area/Pmc/Checkpoint">000137</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000137</idno><idno type="wicri:Area/Ncbi/Merge">000473</idno><idno type="wicri:Area/Ncbi/Curation">000473</idno><idno type="wicri:Area/Ncbi/Checkpoint">000473</idno><idno type="wicri:Area/Main/Merge">000951</idno><idno type="wicri:Area/Main/Curation">000920</idno><idno type="wicri:Area/Main/Exploration">000920</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>DIRAS2</italic> is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders</title><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nguyen, T Trang" sort="Nguyen, T Trang" uniqKey="Nguyen T" first="T Trang" last="Nguyen">T Trang Nguyen</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Medical Biometry and Epidemiology, University of Marburg</institution>, Marburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wei Flog, Lena" sort="Wei Flog, Lena" uniqKey="Wei Flog L" first="Lena" last="Wei Flog">Lena Wei Flog</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</institution>, Wuerzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jacob, Christian P" sort="Jacob, Christian P" uniqKey="Jacob C" first="Christian P" last="Jacob">Christian P. Jacob</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</institution>, Wuerzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J" last="Renner">Tobias J. Renner</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buttenschon, Henriette N" sort="Buttenschon, Henriette N" uniqKey="Buttenschon H" first="Henriette N" last="Buttenschon">Henriette N. Buttenschon</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Centre for Psychiatric Research, Aarhus University Hospital</institution>, Risskov,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kittel Schneider, Sarah" sort="Kittel Schneider, Sarah" uniqKey="Kittel Schneider S" first="Sarah" last="Kittel-Schneider">Sarah Kittel-Schneider</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gessner, Alexandra" sort="Gessner, Alexandra" uniqKey="Gessner A" first="Alexandra" last="Gessner">Alexandra Gessner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weber, Heike" sort="Weber, Heike" uniqKey="Weber H" first="Heike" last="Weber">Heike Weber</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Neuner, Maria" sort="Neuner, Maria" uniqKey="Neuner M" first="Maria" last="Neuner">Maria Neuner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Psychiatry, Psychiatric Neurobiology and Bipolar Disorder Program, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gross Lesch, Silke" sort="Gross Lesch, Silke" uniqKey="Gross Lesch S" first="Silke" last="Gross-Lesch">Silke Gross-Lesch</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</institution>, Wuerzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zamzow, Karin" sort="Zamzow, Karin" uniqKey="Zamzow K" first="Karin" last="Zamzow">Karin Zamzow</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Medical Biometry and Epidemiology, University of Marburg</institution>, Marburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kreiker, Susanne" sort="Kreiker, Susanne" uniqKey="Kreiker S" first="Susanne" last="Kreiker">Susanne Kreiker</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</institution>, Wuerzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Walitza, Susanne" sort="Walitza, Susanne" uniqKey="Walitza S" first="Susanne" last="Walitza">Susanne Walitza</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Department of Child and Adolescent Psychiatry, University of Zuerich</institution>, Zuerich,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Neurobehavioral Genetics, University of Trier, Institute of Psychobiology</institution>, Trier,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Freitag, Christine M" sort="Freitag, Christine M" uniqKey="Freitag C" first="Christine M" last="Freitag">Christine M. Freitag</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Department of Child and Adolescent Psychiatry, Goethe University Frankfurt am Main</institution>, Frankfurt,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bosch, Rosa" sort="Bosch, Rosa" uniqKey="Bosch R" first="Rosa" last="Bosch">Rosa Bosch</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Psychiatry, Hospital Universitari Vall d'Hebron</institution>, Barcelona, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Casas, Miquel" sort="Casas, Miquel" uniqKey="Casas M" first="Miquel" last="Casas">Miquel Casas</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Psychiatry, Hospital Universitari Vall d'Hebron</institution>, Barcelona, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="G Mez, Nuria" sort="G Mez, Nuria" uniqKey="G Mez N" first="Nuria" last="G Mez">Nuria G Mez</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Psychiatry, Hospital Universitari Vall d'Hebron</institution>, Barcelona, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ribases, Marta" sort="Ribases, Marta" uniqKey="Ribases M" first="Marta" last="Ribasès">Marta Ribasès</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Psychiatry, Hospital Universitari Vall d'Hebron</institution>, Barcelona, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bayes, M Nica" sort="Bayes, M Nica" uniqKey="Bayes M" first="M Nica" last="Bayès">M Nica Bayès</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Centro Nacional de Análisis Genómico (CNAG)</institution>, Barcelona, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Buitelaar, Jan K" sort="Buitelaar, Jan K" uniqKey="Buitelaar J" first="Jan K" last="Buitelaar">Jan K. Buitelaar</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</institution>, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kiemeney, Lambertus A L M" sort="Kiemeney, Lambertus A L M" uniqKey="Kiemeney L" first="Lambertus A L M" last="Kiemeney">Lambertus A L M. Kiemeney</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre</institution>, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kooij, J J Sandra" sort="Kooij, J J Sandra" uniqKey="Kooij J" first="J J Sandra" last="Kooij">J J Sandra Kooij</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>PsyQ, Psycho-Medical Programs, Program Adult ADHD</institution>, The Hague,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kan, Cees C" sort="Kan, Cees C" uniqKey="Kan C" first="Cees C" last="Kan">Cees C. Kan</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</institution>, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hoogman, Martine" sort="Hoogman, Martine" uniqKey="Hoogman M" first="Martine" last="Hoogman">Martine Hoogman</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</institution>, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Johansson, Stefan" sort="Johansson, Stefan" uniqKey="Johansson S" first="Stefan" last="Johansson">Stefan Johansson</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Biomedicine, University of Bergen</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jacobsen, Kaya K" sort="Jacobsen, Kaya K" uniqKey="Jacobsen K" first="Kaya K" last="Jacobsen">Kaya K. Jacobsen</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Biomedicine, University of Bergen</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Knappskog, Per M" sort="Knappskog, Per M" uniqKey="Knappskog P" first="Per M" last="Knappskog">Per M. Knappskog</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Medical Genetics and Molecular Medicine, Haukeland University Hospital</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Fasmer, Ole B" sort="Fasmer, Ole B" uniqKey="Fasmer O" first="Ole B" last="Fasmer">Ole B. Fasmer</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Division of Psychiatry, Haukeland University Hospital</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Asherson, Phil" sort="Asherson, Phil" uniqKey="Asherson P" first="Phil" last="Asherson">Phil Asherson</name><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>MRC Social Genetic Developmental and Psychiatry Centre, Institute of Psychiatry</institution>, London,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg</institution>, Würzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Grabe, Hans Jorgen" sort="Grabe, Hans Jorgen" uniqKey="Grabe H" first="Hans-Jörgen" last="Grabe">Hans-Jörgen Grabe</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Psychiatry and Psychotherapy, University of Greifswald</institution>, Greifswald,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mahler, Jessie" sort="Mahler, Jessie" uniqKey="Mahler J" first="Jessie" last="Mahler">Jessie Mahler</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Department of Psychiatry and Psychotherapy, University of Greifswald</institution>, Greifswald,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>, Greifswald,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Institute for Community Medicine, University of Greifswald</institution>, Greifswald,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mors, Ole N" sort="Mors, Ole N" uniqKey="Mors O" first="Ole N" last="Mors">Ole N. Mors</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Centre for Psychiatric Research, Aarhus University Hospital</institution>, Risskov,<country>Denmark</country></nlm:aff><country xml:lang="fr">Danemark</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sch Fer, Helmut" sort="Sch Fer, Helmut" uniqKey="Sch Fer H" first="Helmut" last="Sch Fer">Helmut Sch Fer</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Institute of Medical Biometry and Epidemiology, University of Marburg</institution>, Marburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ramos Quiroga, Josep Antoni" sort="Ramos Quiroga, Josep Antoni" uniqKey="Ramos Quiroga J" first="Josep Antoni" last="Ramos-Quiroga">Josep Antoni Ramos-Quiroga</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Department of Psychiatry, Hospital Universitari Vall d'Hebron</institution>, Barcelona, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cormand, Bru" sort="Cormand, Bru" uniqKey="Cormand B" first="Bru" last="Cormand">Bru Cormand</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Departament de Genètica, Facultat de Biologia, Universitat de Barcelona, and CIBER Enfermedades Raras, and Institut de Biomedicina de la Universitat de Barcelona (IBUB)</institution>, Catalonia,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Haavik, Jan" sort="Haavik, Jan" uniqKey="Haavik J" first="Jan" last="Haavik">Jan Haavik</name><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Department of Biomedicine, University of Bergen</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Division of Psychiatry, Haukeland University Hospital</institution>, Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Department of Psychiatry, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre</institution>, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Human Genetics, Radboud University Nijmegen Medical Center</institution>, Nijmegen,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lesch, Klaus Peter" sort="Lesch, Klaus Peter" uniqKey="Lesch K" first="Klaus-Peter" last="Lesch">Klaus-Peter Lesch</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Department of Psychiatry, ADHD Clinical Research Network, Molecular Psychiatry Laboratory of Translational Neuroscience; Psychosomatics and Psychotherapy, University of Wuerzburg</institution>, Wuerzburg,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Neuropsychopharmacology</title><idno type="ISSN">0893-133X</idno><idno type="eISSN">1740-634X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Several linkage analyses implicated the chromosome 9q22 region in attention deficit/hyperactivity disorder (ADHD), a neurodevelopmental disease with remarkable persistence into adulthood. This locus contains the brain-expressed GTP-binding RAS-like 2 gene (<italic>DIRAS2</italic>) thought to regulate neurogenesis. As <italic>DIRAS2</italic> is a positional and functional ADHD candidate gene, we conducted an association study in 600 patients suffering from adult ADHD (aADHD) and 420 controls. Replication samples consisted of 1035 aADHD patients and 1381 controls, as well as 166 families with a child affected from childhood ADHD. Given the high degree of co-morbidity with ADHD, we also investigated patients suffering from bipolar disorder (BD) (<italic>n</italic>=336) or personality disorders (PDs) (<italic>n</italic>=622). Twelve single-nucleotide polymorphisms (SNPs) covering the structural gene and the transcriptional control region of <italic>DIRAS2</italic> were analyzed. Four SNPs and two haplotype blocks showed evidence of association with ADHD, with nominal <italic>p</italic>-values ranging from <italic>p</italic>=0.006 to <italic>p</italic>=0.05. In the adult replication samples, we obtained a consistent effect of rs1412005 and of a risk haplotype containing the promoter region (<italic>p</italic>=0.026). Meta-analysis resulted in a significant common OR of 1.12 (<italic>p</italic>=0.04) for rs1412005 and confirmed association with the promoter risk haplotype (OR=1.45, <italic>p</italic>=0.0003). Subsequent analysis in nuclear families with childhood ADHD again showed an association of the promoter haplotype block (<italic>p</italic>=0.02). rs1412005 also increased risk toward BD (<italic>p</italic>=0.026) and cluster B PD (<italic>p</italic>=0.031). Additional SNPs showed association with personality scores (<italic>p</italic>=0.008–0.048). Converging lines of evidence implicate genetic variance in the promoter region of <italic>DIRAS2</italic> in the etiology of ADHD and co-morbid impulsive disorders.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Danemark</li><li>Espagne</li><li>Norvège</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li></country></list><tree><country name="Allemagne"><noRegion><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name></noRegion><name sortKey="Freitag, Christine M" sort="Freitag, Christine M" uniqKey="Freitag C" first="Christine M" last="Freitag">Christine M. Freitag</name><name sortKey="Gessner, Alexandra" sort="Gessner, Alexandra" uniqKey="Gessner A" first="Alexandra" last="Gessner">Alexandra Gessner</name><name sortKey="Grabe, Hans Jorgen" sort="Grabe, Hans Jorgen" uniqKey="Grabe H" first="Hans-Jörgen" last="Grabe">Hans-Jörgen Grabe</name><name sortKey="Gross Lesch, Silke" sort="Gross Lesch, Silke" uniqKey="Gross Lesch S" first="Silke" last="Gross-Lesch">Silke Gross-Lesch</name><name sortKey="Jacob, Christian P" sort="Jacob, Christian P" uniqKey="Jacob C" first="Christian P" last="Jacob">Christian P. Jacob</name><name sortKey="Jacob, Christian P" sort="Jacob, Christian P" uniqKey="Jacob C" first="Christian P" last="Jacob">Christian P. Jacob</name><name sortKey="Kittel Schneider, Sarah" sort="Kittel Schneider, Sarah" uniqKey="Kittel Schneider S" first="Sarah" last="Kittel-Schneider">Sarah Kittel-Schneider</name><name sortKey="Kreiker, Susanne" sort="Kreiker, Susanne" uniqKey="Kreiker S" first="Susanne" last="Kreiker">Susanne Kreiker</name><name sortKey="Kreiker, Susanne" sort="Kreiker, Susanne" uniqKey="Kreiker S" first="Susanne" last="Kreiker">Susanne Kreiker</name><name sortKey="Lesch, Klaus Peter" sort="Lesch, Klaus Peter" uniqKey="Lesch K" first="Klaus-Peter" last="Lesch">Klaus-Peter Lesch</name><name sortKey="Mahler, Jessie" sort="Mahler, Jessie" uniqKey="Mahler J" first="Jessie" last="Mahler">Jessie Mahler</name><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><name sortKey="Neuner, Maria" sort="Neuner, Maria" uniqKey="Neuner M" first="Maria" last="Neuner">Maria Neuner</name><name sortKey="Nguyen, T Trang" sort="Nguyen, T Trang" uniqKey="Nguyen T" first="T Trang" last="Nguyen">T Trang Nguyen</name><name sortKey="Renner, Tobias J" sort="Renner, Tobias J" uniqKey="Renner T" first="Tobias J" last="Renner">Tobias J. Renner</name><name sortKey="Romanos, Marcel" sort="Romanos, Marcel" uniqKey="Romanos M" first="Marcel" last="Romanos">Marcel Romanos</name><name sortKey="Sch Fer, Helmut" sort="Sch Fer, Helmut" uniqKey="Sch Fer H" first="Helmut" last="Sch Fer">Helmut Sch Fer</name><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name><name sortKey="Warnke, Andreas" sort="Warnke, Andreas" uniqKey="Warnke A" first="Andreas" last="Warnke">Andreas Warnke</name><name sortKey="Weber, Heike" sort="Weber, Heike" uniqKey="Weber H" first="Heike" last="Weber">Heike Weber</name><name sortKey="Wei Flog, Lena" sort="Wei Flog, Lena" uniqKey="Wei Flog L" first="Lena" last="Wei Flog">Lena Wei Flog</name><name sortKey="Zamzow, Karin" sort="Zamzow, Karin" uniqKey="Zamzow K" first="Karin" last="Zamzow">Karin Zamzow</name></country><country name="Danemark"><noRegion><name sortKey="Buttenschon, Henriette N" sort="Buttenschon, Henriette N" uniqKey="Buttenschon H" first="Henriette N" last="Buttenschon">Henriette N. Buttenschon</name></noRegion><name sortKey="Mors, Ole N" sort="Mors, Ole N" uniqKey="Mors O" first="Ole N" last="Mors">Ole N. Mors</name></country><country name="Suisse"><noRegion><name sortKey="Walitza, Susanne" sort="Walitza, Susanne" uniqKey="Walitza S" first="Susanne" last="Walitza">Susanne Walitza</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Bosch, Rosa" sort="Bosch, Rosa" uniqKey="Bosch R" first="Rosa" last="Bosch">Rosa Bosch</name></noRegion><name sortKey="Bayes, M Nica" sort="Bayes, M Nica" uniqKey="Bayes M" first="M Nica" last="Bayès">M Nica Bayès</name><name sortKey="Casas, Miquel" sort="Casas, Miquel" uniqKey="Casas M" first="Miquel" last="Casas">Miquel Casas</name><name sortKey="Cormand, Bru" sort="Cormand, Bru" uniqKey="Cormand B" first="Bru" last="Cormand">Bru Cormand</name><name sortKey="G Mez, Nuria" sort="G Mez, Nuria" uniqKey="G Mez N" first="Nuria" last="G Mez">Nuria G Mez</name><name sortKey="Ramos Quiroga, Josep Antoni" sort="Ramos Quiroga, Josep Antoni" uniqKey="Ramos Quiroga J" first="Josep Antoni" last="Ramos-Quiroga">Josep Antoni Ramos-Quiroga</name><name sortKey="Ribases, Marta" sort="Ribases, Marta" uniqKey="Ribases M" first="Marta" last="Ribasès">Marta Ribasès</name></country><country name="Pays-Bas"><noRegion><name sortKey="Buitelaar, Jan K" sort="Buitelaar, Jan K" uniqKey="Buitelaar J" first="Jan K" last="Buitelaar">Jan K. Buitelaar</name></noRegion><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><name sortKey="Hoogman, Martine" sort="Hoogman, Martine" uniqKey="Hoogman M" first="Martine" last="Hoogman">Martine Hoogman</name><name sortKey="Kan, Cees C" sort="Kan, Cees C" uniqKey="Kan C" first="Cees C" last="Kan">Cees C. Kan</name><name sortKey="Kiemeney, Lambertus A L M" sort="Kiemeney, Lambertus A L M" uniqKey="Kiemeney L" first="Lambertus A L M" last="Kiemeney">Lambertus A L M. Kiemeney</name><name sortKey="Kooij, J J Sandra" sort="Kooij, J J Sandra" uniqKey="Kooij J" first="J J Sandra" last="Kooij">J J Sandra Kooij</name></country><country name="Norvège"><noRegion><name sortKey="Johansson, Stefan" sort="Johansson, Stefan" uniqKey="Johansson S" first="Stefan" last="Johansson">Stefan Johansson</name></noRegion><name sortKey="Fasmer, Ole B" sort="Fasmer, Ole B" uniqKey="Fasmer O" first="Ole B" last="Fasmer">Ole B. Fasmer</name><name sortKey="Haavik, Jan" sort="Haavik, Jan" uniqKey="Haavik J" first="Jan" last="Haavik">Jan Haavik</name><name sortKey="Haavik, Jan" sort="Haavik, Jan" uniqKey="Haavik J" first="Jan" last="Haavik">Jan Haavik</name><name sortKey="Jacobsen, Kaya K" sort="Jacobsen, Kaya K" uniqKey="Jacobsen K" first="Kaya K" last="Jacobsen">Kaya K. Jacobsen</name><name sortKey="Jacobsen, Kaya K" sort="Jacobsen, Kaya K" uniqKey="Jacobsen K" first="Kaya K" last="Jacobsen">Kaya K. Jacobsen</name><name sortKey="Johansson, Stefan" sort="Johansson, Stefan" uniqKey="Johansson S" first="Stefan" last="Johansson">Stefan Johansson</name><name sortKey="Knappskog, Per M" sort="Knappskog, Per M" uniqKey="Knappskog P" first="Per M" last="Knappskog">Per M. Knappskog</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Asherson, Phil" sort="Asherson, Phil" uniqKey="Asherson P" first="Phil" last="Asherson">Phil Asherson</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000920 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000920 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Rhénanie
|area= UnivTrevesV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3176568
|texte= DIRAS2 is Associated with Adult ADHD, Related Traits, and Co-Morbid Disorders
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21750579" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a UnivTrevesV1
| This area was generated with Dilib version V0.6.31. |  |